Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

INTRODUCTION: Optic neuritis (ON) can be the first manifestation of autoimmune central nervous system diseases such as multiple sclerosis and neuromyelitis optica, but it can also occur as an isolated monophasic or relapsing disease. A proportion of these patients have antibodies against myelin oligodendrocyte glycoprotein (MOG). We report a case of recurrent ON with MOG antibodies in a South Asian patient. CASE REPORT: A 50-year-old Sri Lankan female with a previous history of 2 episodes of steroid-responsive ON presented with a 20/120 visual impairment of her right eye. On examination on admission, visual acuity was noted to be 20/30 on the left and visual evoked potentials were prolonged bilaterally, but all other neurological investigations including screening tests for infections and vasculitis were unremarkable. AQP4 antibodies were negative but MOG antibodies were positive. She responded to intravenous and long-term steroids combined with mycophenolate mofetil, but relapsed when steroids were discontinued. She has been relapse free on low-dose steroids and mycophenolate for 2 years. CONCLUSIONS: Recurrent ON occurs in association with MOG antibodies distinct from neuromyelitis optica and multiple sclerosis, and may require steroid-based immunosuppression to maintain remission. This case report from South Asia adds to map the worldwide occurrence of MOG antibody disease.

Original publication

DOI

10.1097/NRL.0000000000000122

Type

Journal article

Journal

Neurologist

Publication Date

05/2017

Volume

22

Pages

101 - 102

Keywords

Autoantibodies, Female, Humans, Middle Aged, Myelin-Oligodendrocyte Glycoprotein, Optic Neuritis, Recurrence