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Nerve growth factor (NGF) antagonism is on the verge of becoming a powerful analgesic treatment for numerous conditions, including osteoarthritis and lower back pain. This review summarizes the historical research, both fundamental and clinical, that led to our current understanding of NGF biology. We also discuss the surprising number of questions that remain about NGF expression patterns and NGF's various functions and interaction partners in relation to persistent pain and the potential side effects of anti-NGF therapy.

Original publication

DOI

10.1146/annurev-neuro-072116-031121

Type

Journal article

Journal

Annu Rev Neurosci

Publication Date

25/07/2017

Volume

40

Pages

307 - 325

Keywords

chronic pain, nerve growth factor, p75, trkA