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The first cell fate choice in mouse development is the segregation of the embryonic inner cell mass and the extra-embryonic trophectoderm. In this issue of Developmental Cell, Korotkevic and colleagues (2017) show that the interplay between cell polarization and cell-cell contact drives the segregation of these lineages, providing a framework for self-organization in development.

Original publication

DOI

10.1016/j.devcel.2017.01.008

Type

Journal article

Journal

Dev Cell

Publication Date

06/02/2017

Volume

40

Pages

215 - 216