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A crucial factor in maintaining genome stability is establishing deoxynucleoside triphosphate (dNTP) levels within a range that is optimal for chromosomal replication. Since DNA replication is relevant to a wide range of other chromosomal activities, these may all be directly or indirectly affected when dNTP concentrations deviate from a physiologically normal range. The importance of understanding these consequences is relevant to genetic disorders that disturb dNTP levels, and strategies that inhibit dNTP synthesis in cancer chemotherapy and for treatment of other disorders. We review here how abnormal dNTP levels affect DNA replication and discuss the consequences for genome stability.

Original publication

DOI

10.3390/genes8020057

Type

Journal article

Journal

Genes (Basel)

Publication Date

31/01/2017

Volume

8

Keywords

DNA polymerase, dNTP, genome instability, proofreading, replication fidelity, ribonucleotide reductase