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The present study aimed to examine whether the APOE ε4 allele, associated with dementia with Lewy bodies (DLB), and possibly with dementia in Parkinson's disease (PD), is also associated with idiopathic rapid eye movement sleep behavior disorder (RBD). Two single nucleotide polymorphisms, rs429358 and rs7412, were genotyped in RBD patients (n = 480) and in controls (n = 823). APOE ε4 allele frequency was 0.14 among RBD patients and 0.13 among controls (OR = 1.11, 95% CI: 0.88-1.40, p = 0.41). APOE ε4 allele frequencies were similar in those who converted to DLB (0.14) and those who converted to Parkinson's disease (0.12) or multiple system atrophy (0.14, p = 1.0). The APOE ε4 allele is neither a risk factor for RBD nor it is associated with conversion from RBD to DLB or other synucleinopathies.

Original publication

DOI

10.1016/j.neurobiolaging.2016.10.002

Type

Journal article

Journal

Neurobiol Aging

Publication Date

01/2017

Volume

49

Pages

218.e13 - 218.e15

Keywords

APOE, Dementia with Lewy bodies, Genetics, Parkinson's disease, REM sleep behavior disorder, Adolescent, Adult, Alleles, Apolipoproteins E, Female, Gene Frequency, Genetic Association Studies, Humans, Lewy Body Disease, Male, Multiple System Atrophy, Parkinson Disease, Polymorphism, Single Nucleotide, REM Sleep Behavior Disorder, Risk Factors, Supranuclear Palsy, Progressive, Young Adult