Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

The insulin-dependent diabetes (Idd) gene, Idd3, has been localised to a 0.35 cM region of chromosome 3 containing the structural gene for the cytokine interleukin 2 (IL-2). While variation of the N-terminal amino acid sequence of IL-2 has been shown to correlate with Idd3 allelic variation, differences in induction of proliferation by IL-2 allotypes have not been detected. In the current study, we examined the electrophoretic migration of IL-2 allotypes and have found two distinct patterns, consistent with differences in glycosylation, that correlate with diabetes-resistance and susceptibility. These findings strongly suggest that IL-2 variants may be functionally distinct.

Original publication

DOI

10.1006/cyto.1999.0609

Type

Journal article

Journal

Cytokine

Publication Date

05/2000

Volume

12

Pages

477 - 482

Keywords

Alleles, Amino Acid Sequence, Animals, Diabetes Mellitus, Type 1, Electrophoresis, Polyacrylamide Gel, Glycosylation, Interleukin-2, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Inbred NOD, Molecular Sequence Data