Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

A new mouse model linking diabetes, insulin secretion and autoimmunity with a high-fat diet supports a shared mechanism for type 1 (T1D) and type 2 (T2D) diabetes. In this model, the protein secretion system of insulin-producing pancreatic beta cells is stressed, leading to increased beta cell apoptosis and diabetes via reduced levels of the transcription factor GLIS3, a pathogenic pathway that can be mimicked by a high-fat diet.

Original publication

DOI

10.1038/ng.3560

Type

Journal article

Journal

Nat Genet

Publication Date

27/04/2016

Volume

48

Pages

476 - 477

Keywords

Animals, Diabetes Mellitus, Diabetes Mellitus, Type 2, Insulin, Insulin Resistance, Insulin-Secreting Cells, Mice, Mice, Transgenic