Genetics of autoimmune disease.
Merriman TR., Todd JA.
In the past year, the major advances in understanding the genetics of autoimmune disease in both man and mouse have been made as a result of using the positional cloning approach. Construction of congenic mouse strains, and, in humans, the exploitation of linkage disequilibrium between very closely linked markers and disease-predisposing loci, is enabling fine mapping of these loci.