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Development of novel congenic mouse strains has allowed us to better define the location of the diabetogenic locus, Idd3, on Chromosome (Chr) 3. Congenic strains were identified by use of published and newly developed microsatellite markers, their genomes fingerprinted by a rapid, fluorescence-based approach, and their susceptibility to type 1 diabetes evaluated. The maximum interval containing Idd3 is now approximately 4 cM.

Original publication




Journal article


Mamm Genome

Publication Date





563 - 570


Animals, Base Sequence, Chromosome Mapping, DNA Primers, Diabetes Mellitus, Type 1, Female, Humans, Male, Mice, Mice, Inbred C57BL, Mice, Inbred NOD, Molecular Sequence Data, Polymerase Chain Reaction