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The ability to reinstate neuronal assemblies representing mnemonic information is thought to require their consolidation through offline reactivation during sleep/rest. To test this, we detected cell assembly patterns formed by repeated neuronal co-activations in the mouse hippocampus during exploration of spatial environments. We found that the reinstatement of assembly patterns representing a novel, but not a familiar, environment correlated with their offline reactivation and was impaired by closed-loop optogenetic disruption of sharp wave-ripple oscillations. Moreover, we discovered that reactivation was only required for the reinstatement of assembly patterns whose expression was gradually strengthened during encoding of a novel place. The context-dependent reinstatement of assembly patterns whose expression did not gain in strength beyond the first few minutes of spatial encoding was not dependent on reactivation. This demonstrates that the hippocampus can hold concurrent representations of space that markedly differ in their encoding dynamics and their dependence on offline reactivation for consolidation. VIDEO ABSTRACT.

Original publication

DOI

10.1016/j.neuron.2016.10.020

Type

Journal article

Journal

Neuron

Publication Date

07/12/2016

Volume

92

Pages

968 - 974

Keywords

Action Potentials, Animals, Brain Waves, Exploratory Behavior, Hippocampus, Mice, Neurons, Optogenetics, Sleep, Spatial Behavior