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Metabolic cycles result from the partitioning of oxidative and reductive metabolism into rhythmic phases of gene expression and oscillating post-translational protein modifications. Relatively little is known about how these switches in gene expression are controlled, although recent studies have suggested that transcription itself may play a central role. This review explores the molecular basis of the metabolic and gene-expression oscillations in the yeast Saccharomyces cerevisiae, as well as how they relate to other biological time-keeping mechanisms, such as circadian rhythms.

Original publication

DOI

10.1038/nsmb.3311

Type

Journal article

Journal

Nat Struct Mol Biol

Publication Date

06/12/2016

Volume

23

Pages

1035 - 1044

Keywords

Animals, Circadian Rhythm, Gene Expression Regulation, Fungal, Humans, Metabolic Networks and Pathways, Periodicity, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins, Transcriptional Activation, Ultradian Rhythm