Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

The C-terminal domain (CTD) of the large subunit of RNA polymerase (pol) II comprises conserved heptad repeats, and post-translational modification of the CTD regulates transcription and cotranscriptional RNA processing. Recently, the spatial patterns of modification of the CTD repeats have been investigated, and new functions of CTD modification have been revealed. In addition, there are new insights into the roles of the enzymes that decorate the CTD. We review these new findings and reassess the role of the pol II CTD in the regulation of gene expression.

Original publication

DOI

10.1038/nsmb.3285

Type

Journal article

Journal

Nat Struct Mol Biol

Publication Date

06/09/2016

Volume

23

Pages

771 - 777

Keywords

Animals, Consensus Sequence, Cyclin-Dependent Kinase 9, DNA Polymerase II, Gene Expression Regulation, Humans, Phosphorylation, Protein Domains, Protein Processing, Post-Translational, Protein Subunits, Transcription, Genetic