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In a randomized double-blind, parallel groups study, 40 patients undergoing surgical removal of impacted 3rd molar teeth received either midazolam 15 mg orally followed at 35 min by i.v. saline, or oral placebo followed at 35 min by i.v. diazepam 10 mg (Diazemuls). Rapid onset of sedation was seen after midazolam, while the pattern and duration of postoperative sedation, as measured by standard psychometric tests, indicated slower recovery after midazolam than after diazepam. Ratings by the surgeon indicated superior anxiolysis following midazolam and significantly more patients expressed a preference for oral midazolam sedation. Significant, comparable anterograde amnesia was seen with both treatments. No significant cardiovascular complications occurred with either treatment. The findings indicate that rapidly acting oral benzodiazepines such as midazolam provide safe, effect alternatives to i.v. diazepam for conscious sedation in outpatients undergoing minor surgical procedures.


Journal article


Br J Anaesth

Publication Date





746 - 754


Administration, Oral, Adult, Ambulatory Surgical Procedures, Anesthesia, Dental, Anxiety, Clinical Trials as Topic, Diazepam, Double-Blind Method, Humans, Injections, Intravenous, Midazolam, Preanesthetic Medication, Random Allocation, Tooth, Impacted