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A fundamental process in the pathogenesis of Alzheimer's disease (AD) is the breakdown of the cytoskeleton. The microscopic manifestation of this--neurofibrillary tangles--is described. Tangles are formed from paired helical filaments (PHF), in turn constructed from abnormally phosphorylated Tau proteins. Recent investigations on the process of Tau phosphorylation and possible links between amyloid deposition and tangle formation are reviewed.

Type

Journal article

Journal

Curr Opin Neurol Neurosurg

Publication Date

12/1992

Volume

5

Pages

883 - 888

Keywords

Alzheimer Disease, Amyloid beta-Peptides, Amyloid beta-Protein Precursor, Brain, Cytoskeleton, Humans, Neurofibrillary Tangles, tau Proteins