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Recent reports have suggested that variability in the alpha2-macroglobulin gene is a genetic risk factor for Alzheimer's disease. Here we have both tested a common polymorphism in the gene (I1000V) for association with the disease in a four-site case control study design, and tested the locus for linkage in a large series of sibpairs afflicted with late onset disease. Our results fail to show an association between this polymorphism and disease.


Journal article


Neurosci Lett

Publication Date





137 - 139


Age of Onset, Alleles, Alzheimer Disease, Apolipoproteins E, Case-Control Studies, Gene Frequency, Genetic Linkage, Genotype, Humans, Lod Score, Middle Aged, Nuclear Family, Polymorphism, Genetic, Polymorphism, Restriction Fragment Length, alpha-Macroglobulins