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Linkage studies indicate that the same region of chromosome 10 contains a risk locus for late onset Alzheimer disease (LOAD) and a QTL for plasma Abeta42 levels suggesting that a single locus may influence risk for AD by elevating plasma Abeta42 [Ertekin-Taner et al., 2000; Myers et al., 2000]. A strong positional and biological candidate is the urokinase-plasminogen activator (PLAU) gene. Eight polymorphisms spanning the entire gene were examined using case control (CC) and family-based association methods. No association was observed by any method making it unlikely that variation in PLAU explains our linkage data.

Original publication

DOI

10.1002/ajmg.b.20036

Type

Journal article

Journal

Am J Med Genet B Neuropsychiatr Genet

Publication Date

01/01/2004

Volume

124B

Pages

29 - 37

Keywords

Aged, Aged, 80 and over, Alleles, Alzheimer Disease, Case-Control Studies, Chromosomes, Human, Pair 10, Female, Gene Frequency, Genetic Linkage, Genotype, Haplotypes, Humans, Male, Polymorphism, Genetic, Urokinase-Type Plasminogen Activator