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A recent scan of single nucleotide polymorphisms (SNPs) in the region 40-107 Mb on chromosome 10q in a large Japanese case-control cohort identified six SNPs in or near the dynamin-binding protein gene (DNMBP) that were associated with late onset Alzheimer's disease (LOAD) in individuals lacking the APOE epsilon4 allele [Kuwano et al. (2006); Hum Mol Genet 15:2170-2182]. We genotyped these six SNPs in 1,212 unrelated Caucasian patients of UK origin with LOAD and 1,389 ethnically, gender and age matched control subjects. We did not observe a statistically significant association with the risk of LOAD for any of the six SNPs in the sample as a whole. When stratifying the sample by APOE one SNP (intergenic SNP rs11190302) was associated with LOAD in individuals lacking the epsilon4 allele (genotypic P = 0.027, allelic P = 0.066). However this association was in the opposite direction to that detected in the Japanese population. It remains to be determined whether DNMBP is associated with LOAD.

Original publication

DOI

10.1002/ajmg.b.30768

Type

Journal article

Journal

Am J Med Genet B Neuropsychiatr Genet

Publication Date

05/01/2009

Volume

150B

Pages

61 - 64

Keywords

Age of Onset, Alzheimer Disease, Apolipoprotein E4, Chromosomes, Human, Pair 10, Cytoskeletal Proteins, European Continental Ancestry Group, Humans, Polymorphism, Single Nucleotide, United Kingdom