Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Nodal is an evolutionarily conserved member of the transforming growth factor-β (TGF-β) superfamily of secreted signalling factors. Nodal factors are known to play key roles in embryonic development and asymmetry in a variety of organisms ranging from hydra and sea urchins to fish, mice and humans. In addition to embryonic patterning, Nodal signalling is required for maintenance of human embryonic stem cell pluripotency and mis-regulated Nodal signalling has been found associated with tumour metastases. Therefore, precise and timely regulation of this pathway is essential. Here, we discuss recent evidence from sea urchins, frogs, fish, mice and humans that show a role for transcriptional and translational repression of Nodal signalling during early development.

Original publication

DOI

10.1098/rsob.150200

Type

Journal article

Journal

Open Biol

Publication Date

01/2016

Volume

6

Keywords

development, localization, nodal signalling, repression, transcription, translation, Animals, Base Sequence, Humans, Models, Biological, Molecular Sequence Data, Nodal Protein, Protein Biosynthesis, Repressor Proteins, Signal Transduction, Transcription, Genetic