Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Surface glycoproteins direct cellular targeting, attachment, and membrane fusion of arenaviruses and are the primary target for neutralizing antibodies. Despite significant conservation of the glycoprotein architecture across the arenavirus family, there is considerable variation in the molecular recognition mechanisms used during host cell entry. We review recent progress in dissecting these infection events and describe how arenaviral glycoproteins can be targeted by small-molecule antivirals, the natural immune response, and immunoglobulin-based therapeutics. Arenaviral glycoprotein-mediated assembly and infection pathways present numerous opportunities and challenges for therapeutic intervention.

Original publication

DOI

10.1016/j.coviro.2016.04.001

Type

Journal article

Journal

Curr Opin Virol

Publication Date

06/2016

Volume

18

Pages

70 - 75

Keywords

Animals, Antibodies, Neutralizing, Antibodies, Viral, Antiviral Agents, Arenaviridae Infections, Arenavirus, Humans, Membrane Fusion, Membrane Glycoproteins, Mice, Viral Envelope Proteins, Viral Vaccines, Virus Internalization