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Plasmodium falciparum remains one of the most common causes of central nervous system infection worldwide. Recently, differences between the pathophysiology of cerebral malaria in African children and nonimmune adults have been discovered, new syndromes occurring after malaria infection described, and mechanisms for the pathogenesis proposed. In addition, new antimalarial agents have been examined worldwide and initial studies on supportive studies conducted. This paper reviews these new advances, putting them into the perspective of the more established knowledge.

Original publication

DOI

10.1002/ana.410430603

Type

Journal article

Journal

Ann Neurol

Publication Date

06/1998

Volume

43

Pages

695 - 702

Keywords

Adult, Antimalarials, Artemisinins, Child, Humans, Malaria, Cerebral, Quinidine, Quinine, Sesquiterpenes