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The choroid plexus (CP) provides a barrier to entry of toxic molecules from the blood into the brain and transports vital molecules into the cerebrospinal fluid. While a great deal is known about CP physiology, relatively little is known about its immunology. Here, we show immunohistochemical data that help define the role of the CP in innate and adaptive humoral immunity. The results show that complement, in the form of C1q, C3d, C9, or C9neo, is preferentially deposited in stromal concretions. In contrast, immunoglobulin (Ig) G (IgG) and IgA are more often found in CP epithelial cells, and IgM is found in either locale. C4d, IgD, and IgE are rarely, if ever, seen in the CP. In multiple sclerosis CP, basement membrane C9 or stromal IgA patterns were common but were not specific for the disease. These findings indicate that the CP may orchestrate the clearance of complement, particularly by deposition in its concretions, IgA and IgG preferentially via its epithelium, and IgM by either mechanism.

Original publication

DOI

10.1093/jnen/nlw017

Type

Journal article

Journal

J Neuropathol Exp Neurol

Publication Date

05/2016

Volume

75

Pages

415 - 428

Keywords

Cerebrospinal fluid, Choroid plexus, Complement, Concretions, Immunoglobulins, Immunology, Multiple sclerosis., Adaptive Immunity, Adolescent, Adult, Aged, Aged, 80 and over, Basement Membrane, Choroid Plexus, Complement System Proteins, Epithelium, Female, Humans, Immunity, Humoral, Male, Middle Aged, Stromal Cells, Young Adult