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Here, I take a somewhat personal perspective on signalling control, focusing on the rhomboid-like superfamily of proteins that my group has worked on for almost 20 years. As well as describing some of the key and recent advances, I attempt to draw out signalling themes that emerge. One important message is that the genetic and biochemical perspective on signalling has tended to underplay the importance of cell biology. There is clear evidence that signalling pathways exploit the control of intracellular trafficking, protein quality control and degradation and other cell biological phenomena, as important regulatory opportunities.

Original publication

DOI

10.1042/BST20160035

Type

Journal article

Journal

Biochem Soc Trans

Publication Date

15/06/2016

Volume

44

Pages

945 - 950

Keywords

cytokines, growth factors, intracellular transport, rhomboids, Animals, Drosophila Proteins, Humans, Membrane Proteins, Organelles, Protein Transport, Signal Transduction