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The inherited disorders of hemoglobin represent the most common monogenic diseases. This article provides a brief description of the main inherited disorders of hemoglobin and their classification, and summarizes progress made in the last decade toward a better awareness and recognition of these disorders as a global health problem. Also presented are the main demographic, genetic, and environmental factors that influence the present and future health burden of these disorders. The strengths and limitations of existing estimates and current health policies in high-, low-, and middle-income countries are discussed.

Original publication

DOI

10.1016/j.hoc.2015.11.004

Type

Journal article

Journal

Hematol Oncol Clin North Am

Publication Date

04/2016

Volume

30

Pages

327 - 341

Keywords

Consanguinity, Genetic disease, Human migrations, Malaria selection, Newborn screening, Public health, Sickle cell disease, Thalassemias, Cost of Illness, Developing Countries, Global Health, Hemoglobinopathies, Humans, Risk Factors