Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

How plants recognize pathogens and activate defense is still mysterious. Direct interaction between pathogen avirulence (Avr) proteins and plant disease resistance proteins is the exception rather than the rule. During infection, Cladosporium fulvum secretes Avr2 protein into the apoplast of tomato leaves and, in the presence of the extracellular leucine-rich repeat receptor-like Cf-2 protein, triggers a hypersensitive response (HR) that also requires the extracellular tomato cysteine protease Rcr3. We show here that Avr2 binds and inhibits Rcr3 and propose that the Rcr3-Avr2 complex enables the Cf-2 protein to activate an HR.

Original publication

DOI

10.1126/science.1111404

Type

Journal article

Journal

Science

Publication Date

17/06/2005

Volume

308

Pages

1783 - 1786

Keywords

Biotin, Cladosporium, Cysteine Endopeptidases, Cysteine Proteinase Inhibitors, Extracellular Fluid, Fungal Proteins, Hydrogen-Ion Concentration, Immunoprecipitation, Leucine, Lycopersicon esculentum, Pichia, Plant Diseases, Plant Leaves, Plant Proteins, Recombinant Fusion Proteins, Tobacco