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Patients with a clinical diagnosis of Alzheimer's disease were studied using MRI, SPECT, and psychometric tests. Significant correlations between focal perfusion deficits and focal cognitive deficits were found. Significant correlations between regional relaxation time of white matter and psychometric tests of diffuse and focal categories were also found. Pathological examination confirmed Alzheimer's disease as the only diagnosis.


Journal article


Br J Psychiatry

Publication Date





216 - 220


Aged, Alzheimer Disease, Amphetamines, Blood Flow Velocity, Brain, Cerebral Arteries, Cerebral Cortex, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Neuropsychological Tests, Organotechnetium Compounds, Oximes, Psychometrics, Regional Blood Flow, Technetium Tc 99m Exametazime, Tomography, Emission-Computed, Single-Photon