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We have recently developed image processing techniques for measuring the cortical thicknesses of skeletal structures in vivo, with resolution surpassing that of the underlying computed tomography system. The resulting thickness maps can be analysed across cohorts by statistical parametric mapping. Applying these methods to the proximal femurs of osteoporotic women, we discover targeted and apparently synergistic effects of pharmaceutical osteoporosis therapy and habitual mechanical load in enhancing bone thickness.

Original publication




Journal article


PLoS One

Publication Date





Aged, Bone Density, Bone Regeneration, Diagnostic Imaging, Female, Femur, Humans, Middle Aged, Osteoporosis, Tomography, X-Ray Computed, Weight-Bearing