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In this issue, Nagase and colleagues report the discovery of the first selective nonpeptidic orexin 2 receptor (OX2R) agonists. The discovery of these OX2R selective agonists opens up new avenues for therapies related to the activation of the orexin system, especially with respect to the treatment of sleep disorders such as narcolepsy.

Original publication

DOI

10.1021/acs.jmedchem.5b01394

Type

Journal article

Journal

J Med Chem

Publication Date

22/10/2015

Volume

58

Pages

7928 - 7930

Keywords

Animals, Benzamides, Humans, Orexin Receptors, Sulfonamides