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Histone methylation plays fundamental roles in regulating chromatin-based processes. With the discovery of histone demethylases over a decade ago, it is now clear that histone methylation is dynamically regulated to shape the epigenome and regulate important nuclear processes including transcription, cell cycle control and DNA repair. In addition, recent observations suggest that these enzymes could also have functions beyond their originally proposed role as histone demethylases. In this review, we focus on recent advances in our understanding of the molecular mechanisms that underpin the role of histone demethylases in a wide variety of normal cellular processes.

Original publication

DOI

10.15252/embr.201541113

Type

Journal article

Journal

EMBO Rep

Publication Date

12/2015

Volume

16

Pages

1620 - 1639

Keywords

chromatin, demethylase, epigenetics, histone methylation, Animals, Chromatin, DNA Repair, DNA Replication, Epigenesis, Genetic, Histone Demethylases, Histones, Methylation, Mice, Protein Processing, Post-Translational, Replication Origin, Transcription, Genetic