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Eukaryotes and bacteria can be infected with a wide variety of RNA viruses. On average, these pathogens share little sequence similarity and use different replication and transcription strategies. Nevertheless, the members of nearly all RNA virus families depend on the activity of a virally encoded RNA-dependent polymerase for the condensation of nucleotide triphosphates. This review provides an overview of our current understanding of the viral RNA-dependent polymerase structure and the biochemistry and biophysics that is involved in replicating and transcribing the genetic material of RNA viruses.

Original publication

DOI

10.1007/s00018-014-1695-z

Type

Journal article

Journal

Cell Mol Life Sci

Publication Date

11/2014

Volume

71

Pages

4403 - 4420

Keywords

Catalytic Domain, DNA-Directed RNA Polymerases, Promoter Regions, Genetic, Protein Multimerization, RNA Viruses, RNA, Viral