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Large-scale genomic investigations have just begun to illuminate the molecular genetic contributions to major psychiatric illnesses, ranging from small-effect-size common variants to larger-effect-size rare mutations. The findings provide causal anchors from which to understand their neurobiological basis. Although these studies represent enormous success, they highlight major challenges reflected in the heterogeneity and polygenicity of all of these conditions and the difficulty of connecting multiple levels of molecular, cellular, and circuit functions to complex human behavior. Nevertheless, these advances place us on the threshold of a new frontier in the pathophysiological understanding, diagnosis, and treatment of psychiatric disease.

Original publication

DOI

10.1126/science.aaa8954

Type

Journal article

Journal

Science

Publication Date

25/09/2015

Volume

349

Pages

1489 - 1494

Keywords

DNA Mutational Analysis, Genetic Heterogeneity, Genomics, Humans, Mental Disorders, Models, Genetic, Mutation, Risk Factors