Organomediated Enantioselective (18)F Fluorination for PET Applications.
Buckingham F., Kirjavainen AK., Forsback S., Krzyczmonik A., Keller T., Newington IM., Glaser M., Luthra SK., Solin O., Gouverneur V.
The first organomediated asymmetric (18)F fluorination has been accomplished using a chiral imidazolidinone and [(18)F]N-fluorobenzenesulfonimide. The method provides access to enantioenriched (18)F-labeled α-fluoroaldehydes (>90% ee), which are versatile chiral (18)F synthons for the synthesis of radiotracers. The utility of this process is demonstrated with the synthesis of the PET (positron emission tomography) tracer (2S,4S)-4-[(18)F]fluoroglutamic acid.