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The consolidation of memories for places and events is thought to rely, at the network level, on the replay of spatially tuned neuronal firing patterns representing discrete places and spatial trajectories. This occurs in the hippocampal-entorhinal circuit during sharp wave ripple events (SWRs) that occur during sleep or rest. Here, we review theoretical models of lingering place cell excitability and behaviorally induced synaptic plasticity within cell assemblies to explain which sequences or places are replayed. We further provide new insights into how fluctuations in cholinergic tone during different behavioral states might shape the direction of replay and how dopaminergic release in response to novelty or reward can modulate which cell assemblies are replayed.

Original publication

DOI

10.1016/j.tins.2015.07.004

Type

Journal article

Journal

Trends Neurosci

Publication Date

09/2015

Volume

38

Pages

560 - 570

Keywords

acetylcholine, dopamine, hippocampus, replay, sharp-wave ripples, synaptic plasticity, Animals, Brain, Humans, Memory Consolidation, Neuronal Plasticity