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N-methyl-D-aspartate receptor antibodies (NMDAR-Abs) can contribute to neurological relapse after herpes simplex virus encephalitis (HSE). We describe a child with NMDAR-Ab encephalitis after HSE, which was recognized and treated early. We discuss the case in the context of existing reports, and we propose a modified immunotherapy strategy to minimize risk of viral reactivation.

Original publication

DOI

10.1093/jpids/piu054

Type

Journal article

Journal

J Pediatric Infect Dis Soc

Publication Date

06/2015

Volume

4

Pages

e17 - e21

Keywords

HSV, NMDAR, encephalitis, pediatric, plasmapheresis, Acyclovir, Anti-N-Methyl-D-Aspartate Receptor Encephalitis, Antiviral Agents, Autoantibodies, Clonidine, Diazepam, Encephalitis, Herpes Simplex, Encephalomalacia, Female, Fever, Humans, Immunocompromised Host, Immunosuppression, Infant, Leukoencephalopathies, Movement Disorders, Neurological Rehabilitation, Pakistan, Paresis, Phenobarbital, Phenytoin, Plasmapheresis, Receptors, N-Methyl-D-Aspartate, Seizures, Trihexyphenidyl, United Kingdom, Valproic Acid