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Despite substantial advances in our knowledge of immune responses against HIV-1 and of its evolution within the host, it remains unclear why control of the virus eventually breaks down. Here, we present a new theoretical framework for the infection dynamics of HIV-1 that combines antibody and CD8(+) T-cell responses, notably taking into account their different lifespans. Several apparent paradoxes in HIV pathogenesis and genetics of host susceptibility can be reconciled within this framework by assigning a crucial role to antibody responses in the control of viraemia. We argue that, although escape from or progressive loss of quality of CD8(+) T-cell responses can accelerate disease progression, the underlying cause of the breakdown of virus control is the loss of antibody induction due to depletion of CD4(+) T cells. Furthermore, strong antibody responses can prevent CD8(+) T-cell escape from occurring for an extended period, even in the presence of highly efficacious CD8(+) T-cell responses.

Original publication

DOI

10.1098/rstb.2014.0290

Type

Journal article

Journal

Philos Trans R Soc Lond B Biol Sci

Publication Date

19/08/2015

Volume

370

Keywords

AIDS, HIV, T-cell escape, mathematical model, neutralizing antibodies, Antibodies, Neutralizing, CD8-Positive T-Lymphocytes, Disease Progression, HIV Antibodies, HIV Infections, HIV-1, Host-Pathogen Interactions, Humans, Immune Evasion, Models, Immunological, Mutation, Viremia