Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

The ways in which gene transcription is investigated have undergone radical change since the turn of the millennium. Piece-meal approaches focussed upon model genes have increasingly been complemented by genome-wide approaches that allow interrogation of multiple cohorts of genes or even entire genomes. This sea change has been founded upon the increasing availability of whole genome sequences and the attendant evolution of microarray based discovery platforms. Collectively, these approaches are being used to build a global and dynamic perspective of transcription factor occupancy, co-factor recruitment and epigenetic signature. As yet, few of these approaches have been applied to the study of neuronal gene transcription, but this is set to change. Here, I review these key developments and point to their potential application to the study of transcriptional and epigenetic changes in neurons in health and disease.

Original publication

DOI

10.1016/j.pneurobio.2007.07.004

Type

Journal article

Journal

Prog Neurobiol

Publication Date

11/2007

Volume

83

Pages

195 - 210

Keywords

Chromatin, DNA Footprinting, Epigenesis, Genetic, Gene Expression Profiling, Gene Expression Regulation, Histones, Humans, Nerve Tissue Proteins, Neurons, Oligonucleotide Array Sequence Analysis, Transcription, Genetic