Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

We found that optogenetic burst stimulation of hippocampal dopaminergic fibers from midbrain neurons in mice exploring novel environments enhanced the reactivation of pyramidal cell assemblies during subsequent sleep/rest. When applied during spatial learning of new goal locations, dopaminergic photostimulation improved the later recall of neural representations of space and stabilized memory performance. These findings reveal that midbrain dopaminergic neurons promote hippocampal network dynamics associated with memory persistence.

Original publication

DOI

10.1038/nn.3843

Type

Journal article

Journal

Nat Neurosci

Publication Date

12/2014

Volume

17

Pages

1658 - 1660

Keywords

Animals, Dopaminergic Neurons, Hippocampus, Male, Maze Learning, Mesencephalon, Mice, Mice, Transgenic, Neural Pathways, Random Allocation, Spatial Behavior, Spatial Memory