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Caged derivatives of Ca²⁺-mobilizing messengers, such as nicotinic acid adenine dinucleotide phosphate (NAADP), are particularly useful for establishing the effects of these messengers on Ca²⁺ signaling. Caged NAADP is no longer commercially available but can be synthesized in house, as described here. In brief, a stable precursor of the caging reagent is made and converted to an unstable reactive reagent immediately before addition to the compound to be caged.

Original publication

DOI

10.1101/pdb.prot076943

Type

Journal article

Journal

Cold Spring Harb Protoc

Publication Date

01/10/2014

Volume

2014

Keywords

Animals, Calcium, Calcium Signaling, NADP, Photochemistry, Photolysis