Backbone 1H, 13C and 15N resonance assignment of the C-terminal EGF-cbEGF pair of LTBP1 and flanking residues
Robertson IB., Handford PA., Redfield C.
Latent TGFβ binding protein 1 (LTBP1) is a large extracellular protein that has been shown to bind covalently to the propeptide of TGFβ cytokines and form a large latent complex, which is then incapable of binding TGFβ receptors. LTBP1 has also been demonstrated to interact with a number of insoluble extracellular matrix components, such as fibrillin, which may play a role in TGFβ regulation. Here we present the backbone 1 H, 13 C and 15 N assignments for two EGF domains of human LTBP1, and flanking regions, together forming a 12 kDa protein fragment at the C-terminus of LTBP1. This region is of particular interest as it is postulated to be involved in interactions with fibrillin microfibrils. © 2013 Springer Science+Business Media Dordrecht.