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BACKGROUND AND PURPOSE: Patients with genetic background for high circulating oxidized low-density lipoprotein (oxLDL) levels might be at an increased risk of cerebrovascular disease (CVD). METHODS: The association of oxLDL-variant rs676210 with CVD events was studied in patients undergoing coronary angiography (study A; N = 2913 [271 cases]). We sought to replicate the results in a large genome-wide association study meta-analysis of ischaemic stroke (study B; N = 3548 cases, 5972 controls). RESULTS: In study A, the prevalence of hypertension, diabetes and >50% carotid stenosis as well as the levels of LDL cholesterol differed significantly between cases and controls. In a logistic regression model adjusted for the significant covariates, rs676210 associated with CVD events (p = 0.030; odds ratio = 1.29 [95% confidence interval 1.03‒1.63] for risk allele G). In study B, rs676210 did not associate with the history of ischaemic stroke. CONCLUSIONS: The oxLDL levels increasing variant rs676210 associates with CVD events in patients undergoing coronary angiography.

Original publication

DOI

10.1016/j.atherosclerosis.2014.03.002

Type

Journal article

Journal

Atherosclerosis

Publication Date

05/2014

Volume

234

Pages

214 - 217

Keywords

Genetics, Oxidized low-density lipoprotein, Single nucleotide polymorphism, Stroke, Transient ischaemic attack, Brain Ischemia, Cerebrovascular Disorders, Female, Humans, Lipoproteins, LDL, Male, Polymorphism, Single Nucleotide, Stroke