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Memory and orientation were investigated as predictors of underlying Alzheimer's disease (AD) pathology in patients with logopenic (lv) and non-fluent (na) variants of primary progressive aphasia (PPA). Memory and orientation scores from Addenbrooke's Cognitive Examination were compared between 26 lv-PPA, 29 na-PPA, 59 AD, and 90 controls using analysis of variance. Forty-five patients underwent Pittsburgh compound B (PiB) positron emission tomography scans. Patients with lv-PPA performed poorer on memory and orientation than na-PPA and did not differ from the AD group. Post-hoc analysis on the PiB-scanned subgroup corroborated these results. Memory and orientation profiles may supplement language assessment in identifying patients with AD pathology.

Original publication




Journal article


J Alzheimers Dis

Publication Date





33 - 36


Memory, PPA, PiB, lv-PPA, na-PPA, orientation, Adjustment Disorders, Aged, Aged, 80 and over, Aphasia, Primary Progressive, Female, Humans, Language Tests, Male, Memory Disorders, Middle Aged, Neuropsychological Tests, Orientation