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Molecular imaging of tumour tissue focusses mainly on extracellular epitopes such as tumour angiogenesis or signal transduction receptors expressed on the cell membrane. However, most biological processes that define tumour phenotype occur within the cell. In this mini-review, an overview is given of the various techniques to interrogate intracellular events using molecular imaging with radiolabelled compounds. Additionally, similar targeting techniques can be employed for radionuclide therapy using Auger electron emitters, and recent advances in Auger electron therapy are discussed.

Original publication




Journal article


J Labelled Comp Radiopharm

Publication Date





310 - 316


Auger electron, PET, SPECT, cell penetrating peptide, molecular imaging, nuclear localisation sequence, Animals, Cell Nucleus, Epitopes, Humans, Intracellular Space, Molecular Targeted Therapy, Neoplasms, Radionuclide Imaging