Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Behavioral studies indicate that older adults exhibit normal motor sequence learning (MSL), but paradoxically, show impaired consolidation of the new memory trace. However, the neural and physiological mechanisms underlying this impairment are entirely unknown. Here, we sought to identify, through functional magnetic resonance imaging during MSL and electroencephalographic (EEG) recordings during daytime sleep, the functional correlates and physiological characteristics of this age-related motor memory deficit. As predicted, older subjects did not exhibit sleep-dependent gains in performance (i.e., behavioral changes that reflect consolidation) and had reduced sleep spindles compared with young subjects. Brain imaging analyses also revealed that changes in activity across the retention interval in the putamen and related brain regions were associated with sleep spindles. This change in striatal activity was increased in young subjects, but reduced by comparison in older subjects. These findings suggest that the deficit in sleep-dependent motor memory consolidation in elderly individuals is related to a reduction in sleep spindle oscillations and to an associated decrease of activity in the cortico-striatal network.

Original publication

DOI

10.1002/hbm.22426

Type

Journal article

Journal

Hum Brain Mapp

Publication Date

08/2014

Volume

35

Pages

3625 - 3645

Keywords

EEG, aging, cerebellum, fMRI, hippocampus, memory consolidation, motor sequence learning, putamen, sleep, spindles, Adult, Aged, Aging, Brain, Brain Mapping, Electroencephalography, Female, Humans, Learning, Magnetic Resonance Imaging, Male, Memory, Middle Aged, Motor Activity, Photoperiod, Sleep, Young Adult