Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

CD47 is a broadly expressed membrane protein that interacts with the myeloid inhibitory immunoreceptor SIRPα (also termed CD172a or SHPS-1). SIRPα is the prototypic member of the SIRP paired receptor family of closely related SIRP proteins. Engagement of SIRPα by CD47 provides a downregulatory signal that inhibits host cell phagocytosis, and CD47 therefore functions as a "don't-eat-me" signal. Here, we discuss recent structural analysis of CD47-SIRPα interactions and implications of this for the function and evolution of SIRPα and paired receptors in general. Furthermore, we review the proposed roles of CD47-SIRPα interactions in phagocytosis, (auto)immunity, and host defense, as well as its potential significance as a therapeutic target in cancer and inflammation and for improving graft survival in xenotransplantation.

Original publication

DOI

10.1146/annurev-immunol-032713-120142

Type

Journal article

Journal

Annu Rev Immunol

Publication Date

2014

Volume

32

Pages

25 - 50

Keywords

Animals, Antigens, Differentiation, Autoimmune Diseases, CD47 Antigen, Dendritic Cells, Hematologic Diseases, Humans, Immunological Synapses, Molecular Targeted Therapy, Multigene Family, Neoplasms, Phagocytosis, Protein Binding, Receptors, Immunologic, Signal Transduction, T-Lymphocytes