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The frequency of alpha+-thalassaemia, but not other unlinked DNA polymorphisms, exhibits an altitude- and latitude-dependent correlation with malaria endemicity throughout Melanesia, supporting the hypothesis that protection against this parasitic disease is the major factor responsible for the high frequencies of haemoglobinopathies in many parts of the world.

Original publication

DOI

10.1038/321744a0

Type

Journal article

Journal

Nature

Publication Date

19/06/1986

Volume

321

Pages

744 - 750

Keywords

Altitude, Gene Frequency, Genotype, Humans, Malaria, Melanesia, New Guinea, Selection, Genetic, Thalassemia