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Transcription and replication of the influenza A virus RNA genome are mediated by the viral RNA polymerase from a promoter consisting of the partially base-paired 3' and 5' termini of viral genome segments. Here we show that transcription and replication can be uncoupled by mutation of an unpaired adenosine in the 5' strand of the promoter. This residue is important for transcription but not replication by being essential for the cap-binding activity of the RNA polymerase.

Original publication

DOI

10.1128/JVI.00636-13

Type

Journal article

Journal

J Virol

Publication Date

09/2013

Volume

87

Pages

10381 - 10384

Keywords

Adenosine, Influenza A virus, Point Mutation, Promoter Regions, Genetic, Protein Binding, RNA Replicase, RNA, Viral, Transcription, Genetic, Virus Replication