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Experimental recordings of transmural activation in the human left ventricle show variability in recorded activation times. In this paper we demonstrate a framework for fitting the conductivity tensor of a monodomain model to reproduce activation times for an individual experiment whilst taking into account uncertainty in the fibre orientation. By directly registering anatomical features onto the difference between simulated and experimental results, we are then able to identify structural heterogeneities which impact on conduction in the left ventricle. © 2013 Springer-Verlag.

Original publication




Conference paper

Publication Date



7945 LNCS


224 - 231