Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Progress in complex trait mapping in mice has been accelerated by the development of new populations suited to high-resolution mapping and by statistical methodologies that control for population structure. When combined with newly acquired catalogs of sequence variation in inbred strains, the genetic architecture of these new populations makes it possible to dissect complex traits down to the level of single variants. These analyses have shown not only that complex traits are caused by multiple contributing loci but also that each locus is likely due to the combined effects of multiple causal DNA variants. In combination with new rapid methods for producing transgenic mice that make it efficient to test candidate genes and variants, these advances significantly enhance the mouse genetics toolbox for dissecting quantitative traits.

Original publication

DOI

10.1146/annurev-genom-091212-153419

Type

Journal article

Journal

Annu Rev Genomics Hum Genet

Publication Date

2013

Volume

14

Pages

421 - 439

Keywords

Animals, Genetic Variation, Genetics, Population, Mice, Mice, Inbred Strains, Phenotype, Quantitative Trait Loci