Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Rgs2 (regulator of G-protein signalling 2) gene recently was reported as a quantitative trait gene for anxious behaviour in mice and male Rgs2 knockout mice have been shown to be more anxious than wildtype mice. Therefore we investigated four non-coding single nucleotide polymorphisms in a sample of 173 patients with panic disorder and 173 matched controls of German descent. At the genotype level all four SNPs were associated with panic disorder (p = 0.02-0.05). At the haplotype level the strongest association was observed for a haplotype containing SNP3 and SNP 4 (subgroup men and men with agoraphobia: p = 0.01 and 0.03). This points towards a functional polymorphism at the 3' end of the gene. Our results support the hypothesis that variations of the Rgs2 gene play a role also for the development of anxiety in humans.

Original publication




Journal article


J Neural Transm (Vienna)

Publication Date





1921 - 1925


Agoraphobia, Anxiety, Case-Control Studies, Chromosomes, Human, Pair 1, DNA Primers, Humans, Linkage Disequilibrium, Odds Ratio, Panic Disorder, Polymorphism, Single Nucleotide, Psychiatric Status Rating Scales, RGS Proteins, Reverse Transcriptase Polymerase Chain Reaction