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Rgs2 (regulator of G-protein signalling 2) gene recently was reported as a quantitative trait gene for anxious behaviour in mice and male Rgs2 knockout mice have been shown to be more anxious than wildtype mice. Therefore we investigated four non-coding single nucleotide polymorphisms in a sample of 173 patients with panic disorder and 173 matched controls of German descent. At the genotype level all four SNPs were associated with panic disorder (p = 0.02-0.05). At the haplotype level the strongest association was observed for a haplotype containing SNP3 and SNP 4 (subgroup men and men with agoraphobia: p = 0.01 and 0.03). This points towards a functional polymorphism at the 3' end of the gene. Our results support the hypothesis that variations of the Rgs2 gene play a role also for the development of anxiety in humans.

Original publication

DOI

10.1007/s00702-006-0484-8

Type

Journal article

Journal

J Neural Transm (Vienna)

Publication Date

12/2006

Volume

113

Pages

1921 - 1925

Keywords

Agoraphobia, Anxiety, Case-Control Studies, Chromosomes, Human, Pair 1, DNA Primers, Humans, Linkage Disequilibrium, Odds Ratio, Panic Disorder, Polymorphism, Single Nucleotide, Psychiatric Status Rating Scales, RGS Proteins, Reverse Transcriptase Polymerase Chain Reaction