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MicroRNAs are a class of small RNAs that are increasingly being recognized as important regulators of gene expression. Although hundreds of microRNAs are present in the mammalian genome, genetic studies addressing their physiological roles are at an early stage. We have shown that mice deficient for bic/microRNA-155 are immunodeficient and display increased lung airway remodeling. We demonstrate a requirement of bic/microRNA-155 for the function of B and T lymphocytes and dendritic cells. Transcriptome analysis of bic/microRNA-155-deficient CD4+ T cells identified a wide spectrum of microRNA-155-regulated genes, including cytokines, chemokines, and transcription factors. Our work suggests that bic/microRNA-155 plays a key role in the homeostasis and function of the immune system.

Original publication

DOI

10.1126/science.1139253

Type

Journal article

Journal

Science

Publication Date

27/04/2007

Volume

316

Pages

608 - 611

Keywords

3' Untranslated Regions, Animals, B-Lymphocytes, Cytokines, Dendritic Cells, Gene Expression Regulation, Gene Targeting, Homeostasis, Immune System, Immunoglobulin G, Lung, Lung Diseases, Lymphocyte Activation, Mice, MicroRNAs, Oligonucleotide Array Sequence Analysis, Proto-Oncogene Proteins c-maf, Salmonella Infections, Animal, T-Lymphocytes, Th1 Cells, Th2 Cells, Vaccination