Catalytic hydrotrifluoromethylation of unactivated alkenes.
Mizuta S., Verhoog S., Engle KM., Khotavivattana T., O'Duill M., Wheelhouse K., Rassias G., Médebielle M., Gouverneur V.
A visible-light-mediated hydrotrifluoromethylation of unactivated alkenes that uses the Umemoto reagent as the CF(3) source and MeOH as the reductant is disclosed. This effective transformation operates at room temperature in the presence of 5 mol % Ru(bpy)(3)Cl(2); the process is characterized by its operational simplicity and functional group tolerance.